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GRPS are constructed in two steps: firstly, individual effect sizes of risk alleles (e.beta from linear regression, odds ratio from logistic regression or trading platform bitcoin linear unbiased prediction (BLUP) from linear-mixed models (Yang et al.

Secondly, for each individual within the target sample a GRPS is computed by taking the number of risk alleles an trading platform bitcoin possesses weighted by the effect size of that allele from the discovery sample, averaged over the number of loci included in the GRPS.

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